Blink^TM NutriTears^® is administered as one soft-gel capsule taken orally each day with food.

Lutein, zeaxanthin, curcumin, and vitamin D3 have demonstrated protective and anti-inflammatory properties in ocular models. Clinical studies showed that Blink^TM NutriTears^® improves symptoms of dry eye disease, reduces inflammatory markers and improves corneal and conjunctival staining.

Although omega-3 fatty acid supplementation has been widely studied, contrasting findings, short duration and low-quality data mean there is no definitive evidence of efficacy and a lack of consensus to guide optimal treatment. A recent, large, 12-month clinical study of omega-3 fatty acids did not show any benefit in patient symptoms or signs versus placebo. Further work needs to clearly establish a benefit for omega-3 in eye health.

Lutein and zeaxanthin are carotenoid pigments uniquely concentrated in the human macula. Following ingestion as a supplement, lutein has demonstrated antioxidant and anti-inflammatory effects, protecting the retina against photo-oxidative damage and inflammatory cytokine production caused by exposure to blue light.

Vitamin D3 is a prohormone, with antioxidant, immunomodulatory, and anti-inflammatory properties, which can affect the functions of corneal epithelial cells, including barrier provision and response to inflammation and infection.

In vitro, vitamin D3 exerts anti-inflammatory effects on the cornea by inhibiting stress-induced cellular inflammation or modifying signaling to reduce secretion of proinflammatory cytokines.

In patients with DED, low levels of vitamin D3 are associated with increased DED severity, poor tear film stability, and reduced tear volume.

In vitro, curcumin can reduce proinflammatory cytokines in corneal epithelial cells and act as a neuroprotector of retina precursor cells. When used as a supplement in patients with wet age-related macular degeneration (AMD), alongside anti-vascular endothelial growth factor injections, curcumin improved visual acuity and reduced the total number of injections patients needed.

There is no need to stop use of eye drops while using Blink^TM NutriTears^®. Patients should discuss any changes to their treatment plan with their healthcare provider.

The Blink^TM NutriTears^® clinical studies enrolled patients with all types of clinically diagnosed dry eye disease. Benefits were reported for all patient types.

Currently, tolerable upper intake levels have not been set for lutein or zeaxanthin and clinical data is not available for patients taking both Blink^TM NutriTears^® and AREDS/AREDS2 formula dietary supplements. However, carotenoids such as lutein and zeaxanthin supplements are generally regarded as safe (GRAS) by the Food and Drug Administration (FDA).

Concomitant use of Blink^TM NutriTears^® and Omega-3 supplements has not been studied; however, there is no overlap of ingredients and no known contraindications. Please consult your doctor for more information.